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Article

Next-generation sequencing of microRNAs uncovers expression signatures in polarized macrophages.

Physiological genomics - 1 Feb 2014

Cobos Jiménez Viviana, Bradley Edward J, Willemsen Antonius M, van Kampen Antoine H C, Baas Frank, Kootstra Neeltje A

Abstract excerpt

microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at a posttranscriptional level and play a crucial role in the development of cells of the immune system. Macrophages are essential for generating inflammatory reactions upon tissue damage and encountering of invading pathogens, yet modulation of their immune responses is critical for maintaining tissue homeostasis. Macrophages can present...

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PMID: 24326348
DOI: 10.1152/physiolgenomics.00140.2013

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