Article
Heterogeneity of macrophages in atherosclerosis revealed by single-cell RNA sequencing.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2023
Yu Liwen, Zhang Yujie, Liu Changhao, Wu Xiao, Wang Shasha, Sui Wenhai, Zhang Yun, Zhang Cheng, Zhang Meng
Abstract excerpt
Technology at the single-cell level has advanced dramatically in characterizing molecular heterogeneity. These technologies have enabled cell subtype diversity to be seen in all tissues, including atherosclerotic plaques. Critical in atherosclerosis pathogenesis and progression are macrophages. Previous studies have only determined macrophage phenotypes within the plaque, mainly by bulk analysis. However, recent...
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