Article

Targeting Epsins by nanotherapy regulates lipid metabolism and promotes ABCG1-mediated cholesterol efflux to fortify atheroma regression

2022-08-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Excess cholesterol accumulation in lesional macrophages elicits complex responses in atherosclerosis. Epsins, a family of endocytic adaptors, fuel the progression of atherosclerosis; however, the underlying mechanism and therapeutic potential of targeting Epsins remains unknown. In this study, we determined the role of Epsins in macrophage-mediated metabolic regulation. We t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c74f6e1d-2c60-59d6-8982-c5fc8d8f8458
DOI: 10.1101/2022.08.09.503334

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting Epsins by nanotherapy regulates lipid metabolism and promotes ABCG1-mediated cholesterol efflux to fortify atheroma regressionDOI 10.1101/2022.08.09.503334Read

Single-Cell Analysis Reveals a Critical Role for Macrophage Epsins in Regulating the Origin of Foam Cells in Atherosclerosis.Semantic proximity Read

Targeting Liver Epsins Ameliorates Dyslipidemia in Atherosclerosis through Inhibition of Proprotein Convertase Subtilisin/Kexin Type 9-Mediated Low-density Lipoprotein Receptor DegradationSemantic proximity Read

Chronic Polystyrene Nanoplastics Exposure Reprograms Gene Expression, Alternative Splicing, and Disrupts Host–Microbiome–Metabolic Networks to Promote Atherosclerosis in LDLr⁻/⁻ MiceSemantic proximity Read

miR487a-3p and miR6855-3p Facilitate Macrophage Pro-inflammatory Polarization and Lipid Accumulation in AtherosclerosisSemantic proximity Read

Epsins oversee smooth muscle cell reprograming by influencing master regulators KLF4 and OCT4Semantic proximity Read

Single-cell to pre-clinical evaluation of Trem2, Folr2, and Slc7a7 as macrophage-associated biomarkers for atherosclerosis.Semantic proximity Read

A drug-free, engineered hybrid exosome platform alleviates atherosclerosis via inflammation modulation and phenotype remodeling.Semantic proximity Read

Targeted delivery of RNA-based therapeutics enables functional analysis of macrophage subpopulationsSemantic proximity Read

Stage-resolved Spatial Multi-omics Reveals Myeloid Niches in Human Atherosclerotic PlaquesSemantic proximity Read

Impact of S100A4 Deletion on the Macrophage Metabolome and DifferentiationSemantic proximity Read

LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8Semantic proximity Read

Integrated application of transcriptome and metabolomics reveals potential therapeutic targets for the polarization of atherosclerotic macrophagesSemantic proximity Read