Article

Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity

2018-01-24

Abstract excerpt

<h4>SUMMARY</h4> Multi-region sequencing is used to detect intratumor genetic heterogeneity (ITGH) in tumors. To assess whether genuine ITGH can be distinguished from sequencing artifacts, we whole-exome sequenced (WES) three anatomically distinct regions of the same tumor with technical replicates to estimate technical noise. Somatic variants were detected with three different WES pipelines and subsequently vali...

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Literature Corpus work: 5ee77791-3d47-5f5e-b50f-0e97235cb555
DOI: 10.1101/253195

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