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Article

Assessing reliability of intra-tumor heterogeneity estimates from single sample whole exome sequencing data.

PloS one - 1 Jan 2019

Abécassis Judith, Hamy Anne-Sophie, Laurent Cécile, Sadacca Benjamin, Bonsang-Kitzis Hélène, Reyal Fabien, Vert Jean-Philippe

Abstract excerpt

Tumors are made of evolving and heterogeneous populations of cells which arise from successive appearance and expansion of subclonal populations, following acquisition of mutations conferring them a selective advantage. Those subclonal populations can be sensitive or resistant to different treatments, and provide information about tumor aetiology and future evolution. Hence, it is important to be able to assess...

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Identifiers

PMID: 31697689
DOI: 10.1371/journal.pone.0224143
PMCID: PMC6837753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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