Article

Assessing reliability of intra-tumor heterogeneity estimates from single sample whole exome sequencing data

2018-10-11

Abstract excerpt

Tumors are made of evolving and heterogeneous populations of cells which arise from successive appearance and expansion of subclonal populations, following acquisition of mutations conferring them a selective advantage. Those subclonal populations can be sensitive or resistant to different treatments, and provide information about tumor aetiology and future evolution. Hence, it is important to be able to assess th...

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Literature Corpus work: ab609ad2-a96d-5f86-a663-6147a4b8aeca
DOI: 10.1101/440750

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