Article

Intratumoral heterogeneity in microsatellite instability at single cell resolution

2025-06-14

Abstract excerpt

Subclonal diversity within a tumor is highly relevant for tumor evolution and treatment. This diversity is often referred to as intratumoral heterogeneity and is known to complicate the interpretation of single-test biomarkers. Microsatellite instability (MSI) is one such biomarker, which is used to guide immune check-point inhibitor treatment through the classification of samples as either having high microsatell...

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Literature Corpus work: 82eb9505-92ea-5360-a489-db45f71a569e
DOI: 10.1101/2025.06.11.658021

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