Article

LoLoPicker: Detecting Low Allelic-Fraction Variants in Low-Quality Cancer Samples

2016-03-15

Abstract excerpt

<h4>Summary</h4> We developed an efficient tool dedicated to call somatic variants from whole-exome sequencing (WES) data using tumor and its matched normal tissue, plus a user-defined control panel of non-cancer samples. Compared with other methods, we showed superior performance of LoLoPicker with significantly improved specificity. The algorithm of LoLoPicker is particularly useful for calling variants from lo...

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Literature Corpus work: 17777f4c-6380-5289-9437-20e4e61cde32
DOI: 10.1101/043612

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