Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intratumoral heterogeneity of intrahepatic cholangiocarcinoma.

Oncotarget - 28 Feb 2017

Walter Dirk, Döring Claudia, Feldhahn Magdalena, Battke Florian, Hartmann Sylvia, Winkelmann Ria, Schneider Markus, Bankov Katrin, Schnitzbauer Andreas, Zeuzem Stefan, Hansmann Martin Leo, Peveling-Oberhag Jan

Abstract excerpt

No personalized therapy regimens could demonstrate a benefit in survival of intrahepatic cholangiocarcinoma (iCCA). Since genetic heterogeneity might influence single biopsy based targeted therapy or the outcome of clinical trials, aim of the present study was to investigate intratumoral heterogeneity of iCCA by whole exome sequencing. Therefore, samples from tumor center and tumor periphery of large iCCA lesions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bile Duct Neoplasms
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholangiocarcinoma

Share to DNA Copy Number Variations

Share to High-Throughput Nucleotide Sequencing

Share to Neoplasm Staging

Share to Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 28146430
DOI: 10.18632/oncotarget.14844
PMCID: PMC5362457

Genes

MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intratumoral heterogeneity of intrahepatic cholangiocarcinoma.PMID 28146430Read ↗

Spatial and temporal clonal evolution of intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

IDH Mutation Subgroup Status Associates with Intratumor Heterogeneity and the Tumor Microenvironment in Intrahepatic Cholangiocarcinoma.Semantic proximity Read ↗

Heterogeneity of small duct- and large duct-type intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations.Semantic proximity Read ↗

Genetic heterogeneity in cholangiocarcinoma: a major challenge for targeted therapies.Semantic proximity Read ↗

Genomic profiling of multifocal intrahepatic cholangiocarcinoma reveals intraindividual concordance of genetic alterationsSemantic proximity Read ↗

Charting co-mutation patterns associated with actionable drivers in intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

Molecular profiling of intrahepatic and extrahepatic cholangiocarcinoma using next generation sequencing.Semantic proximity Read ↗

Cholangiocarcinoma Heterogeneity Revealed by Multigene Mutational Profiling: Clinical and Prognostic Relevance in Surgically Resected Patients.Semantic proximity Read ↗

Genomic profiling of intrahepatic cholangiocarcinoma: refining prognosis and identifying therapeutic targets.Semantic proximity Read ↗

Intrahepatic Cholangiocarcinoma: Genomic Heterogeneity Between Eastern and Western PatientsSemantic proximity Read ↗

Circumventing intratumoral heterogeneity to identify potential therapeutic targets in hepatocellular carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.