Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity

1 Nov 2018

Abstract excerpt

Multi-region sequencing is used to detect intratumor genetic heterogeneity (ITGH) in tumors. To assess whether genuine ITGH can be distinguished from sequencing artifacts, we performed whole-exome sequencing (WES) on three anatomically distinct regions of the same tumor with technical replicates to estimate technical noise. Somatic variants were detected with three different WES pipelines and subsequently...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Epigenetics and DNA Methylation
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30404001
DOI: 10.1016/j.celrep.2018.10.046

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic HeterogeneityPMID 30404001Read ↗

Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic HeterogeneitySemantic proximity Read ↗

Deciphering intratumor heterogeneity using cancer genome analysis.Semantic proximity Read ↗

Assessing reliability of intra-tumor heterogeneity estimates from single sample whole exome sequencing data.Semantic proximity Read ↗

Assessing reliability of intra-tumor heterogeneity estimates from single sample whole exome sequencing dataSemantic proximity Read ↗

Intratumoral heterogeneity of intrahepatic cholangiocarcinoma.Semantic proximity Read ↗

SNP arrays in heterogeneous tissue: highly accurate collection of both germline and somatic genetic information from unpaired single tumor samples.Semantic proximity Read ↗

Intra-tumor genetic heterogeneity in rectal cancer.Semantic proximity Read ↗

Multiple region whole-exome sequencing reveals dramatically evolving intratumor genomic heterogeneity in esophageal squamous cell carcinomaSemantic proximity Read ↗

Accuracy of somatic variant detection in multiregional tumor sequencing dataSemantic proximity Read ↗

Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution.Semantic proximity Read ↗

Intratumoral heterogeneity in microsatellite instability at single cell resolutionSemantic proximity Read ↗

Intra‐tumor heterogeneity in head and neck cancer and its clinical implicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.