Article

A robust penalized-regression-based method for multivariable Mendelian randomization using GWAS summary statistics

2023-10-03

Abstract excerpt

<title>Abstract</title> <p>Mendelian randomization (MR) is a statistical approach to inferring the causal relationships from genome-wide association studies (GWAS) by using genetic variants as instrumental variables (IVs). As IVs, the selected genetic variants should be solely associated with the exposure of interest, and have no associations with confounders and the studied outcome except through the exposure. S...

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Literature Corpus work: 12f1e636-6b49-5128-a98b-ea05a4f08e73
DOI: 10.21203/rs.3.rs-3229244/v1

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