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Article

An efficient and robust approach to Mendelian randomization with measured pleiotropic effects in a high-dimensional setting.

Biostatistics (Oxford, England) - 13 Apr 2022

Grant Andrew J, Burgess Stephen

Abstract excerpt

Valid estimation of a causal effect using instrumental variables requires that all of the instruments are independent of the outcome conditional on the risk factor of interest and any confounders. In Mendelian randomization studies with large numbers of genetic variants used as instruments, it is unlikely that this condition will be met. Any given genetic variant could be associated with a large number of traits,...

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Identifiers

PMID: 33155035
DOI: 10.1093/biostatistics/kxaa045
PMCID: PMC9007434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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