Article

AnkG-Neurofascin complex structure reveals binding mechanisms required for integrity of the AIS

2022-04-28

Abstract excerpt

The axon initial segment (AIS) has characteristically clustering of voltage-gated sodium channels (Nav), cell adhesion molecule Neurofascin (Nfasc), and neuronal scaffold protein Ankyrin-G (AnkG) in neurons, which facilitate generation of action potential and maintenance of axonal polarity. However, the mechanisms underlying AIS assembly and maintenance remain poorly understood. Here we report the high-resolution...

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Literature Corpus work: 5ed0846f-4142-5605-9f92-82d0db4a09fc
DOI: 10.1101/2022.04.27.489743

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