Article
Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling.
Proceedings of the National Academy of Sciences of the United States of America - 27 Jan 2015
Jenkins Paul M, Kim Namsoo, Jones Steven L, Tseng Wei Chou, Svitkina Tatyana M, Yin Henry H, Bennett Vann
Abstract excerpt
Axon initial segments (AISs) and nodes of Ranvier are sites of clustering of voltage-gated sodium channels (VGSCs) in nervous systems of jawed vertebrates that facilitate fast long-distance electrical signaling. We demonstrate that proximal axonal polarity as well as assembly of the AIS and normal morphogenesis of nodes of Ranvier all require a heretofore uncharacterized alternatively spliced giant exon of...
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