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Filamin A in focus: unravelling the multifaceted roles of filamin A in neurodevelopment and neurological disorders

14 May 2025

Abstract excerpt

Neurodevelopment is an intricate process encompassing the proliferation, differentiation, migration and maturation of neural cells. Disruptions in these tightly regulated events can lead to a variety of neurodevelopmental disorders. Filamin A (FLNA), a key actin-binding protein, plays a pivotal role in regulating neuronal migration, morphological development and synaptic connectivity by modulating actin...

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PMID: 40365811
DOI: 10.1093/brain/awaf180

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Related research

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Research trail→

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Filamin A in focus: unravelling the multifaceted roles of filamin A in neurodevelopment and neurological disordersPMID 40365811Read ↗

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Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: Insights into the cause of periventricular heterotopiaSemantic proximity Read ↗

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