Article
Neurofascins are required to establish axonal domains for saltatory conduction.
Neuron - 8 Dec 2005
Sherman Diane L, Tait Steven, Melrose Shona, Johnson Richard, Zonta Barbara, Court Felipe A, Macklin Wendy B, Meek Stephen, Smith Andrew J H, Cottrell David F, Brophy Peter J
Abstract excerpt
Voltage-gated sodium channels are concentrated in myelinated nerves at the nodes of Ranvier flanked by paranodal axoglial junctions. Establishment of these essential nodal and paranodal domains is determined by myelin-forming glia, but the mechanisms are not clear. Here, we show that two isoforms of Neurofascin, Nfasc155 in glia and Nfasc186 in neurons, are required for the assembly of these specialized domains....
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