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DNA methylation and gene expression analysis in adipose tissue to identify new loci associated with T2D development in obesity

19 Dec 2022

Abstract excerpt

BACKGROUND: Obesity is accompanied by excess adipose fat storage, which may lead to adipose dysfunction, insulin resistance, and type 2 diabetes (T2D). Currently, the tendency to develop T2D in obesity cannot be explained by genetic variation alone-epigenetic mechanisms, such as DNA methylation, might be involved. Here, we aimed to identify changes in DNA methylation and gene expression in visceral adipose tissue...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 36535927
DOI: 10.1038/s41387-022-00228-w

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