Article

Evaluation of anti insulin receptor antibodies as potential novel therapies for human insulin receptoropathy

2017-11-22

Abstract excerpt

Biallelic loss-of-function mutations in the insulin receptor (INSR) commonly cause extreme insulin resistance and early mortality. Therapeutic options are limited, but anti-INSR antibodies have previously been shown to activate two mutant receptors. This study evaluated four murine anti-INSR monoclonal antibodies, each capable of stimulating wildtype INSR signaling, against ten known pathogenic INSR mutants and on...

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Literature Corpus work: 5eb3f0f1-c47a-5a9d-a6b3-c2a8b95df4f9
DOI: 10.1101/223883

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