Functional characteristics of insulin receptors with a Thr-->Ser1200 mutation overexpressed in Chinese hamster ovary cells.

doi:10.1530/eje.0.1430125

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Article

Functional characteristics of insulin receptors with a Thr-->Ser1200 mutation overexpressed in Chinese hamster ovary cells.

European journal of endocrinology - 1 Jul 2000

Schütt M, Benecke H, Drenckhan M, Klein H H

Abstract excerpt

OBJECTIVE: To investigate the functional properties of insulin receptors with a Thr-->Ser(1200)-mutation that is associated with severe insulin resistance in humans. DESIGN AND METHODS: The effect of in situ insulin-stimulation on insulin receptor kinase activity was studied in Chinese hamster ovary cells with overexpressed human Ser(1200)-mutated, non-mutated, and ATP-binding site-mutated (Lys-->Arg(1030))...

Topics

Alkaline Phosphatase
Animals
CHO Cells
Cricetinae
Enzyme Activation
Gene Expression
Humans
Insulin
Insulin-Like Growth Factor I
Mutation
Phosphorylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinases

Receptor, Insulin

Serine

Swine

Threonine

Transfection

Source

Open in PubMed

Identifiers

PMID: 10870041
DOI: 10.1530/eje.0.1430125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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