Article

Anti-Insulin receptor antibodies improve hyperglycaemia in a mouse model of human insulin receptoropathy

2020-03-20

Abstract excerpt

Loss-of-function mutations in both alleles of the human insulin receptor gene (INSR) cause extreme insulin resistance (IR) and usually death in childhood, with few therapeutic options. Bivalent anti-receptor antibodies can elicit insulin-like signaling by mutant INSR in cultured cells, but whether this translates into meaningful metabolic benefits in vivo , where dynamics of insulin signaling and receptor recycli...

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Literature Corpus work: 56f2027a-a062-5135-8d0b-65088b06dcba
DOI: 10.1101/2020.03.20.999771

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