Article
Optimization of a Glucagon-Like Peptide 1 Receptor Antagonist Antibody for Treatment of Hyperinsulinism.
Diabetes - 1 Sept 2023
Peterson Sean M, Juliana Christine A, Hu Cameron F, Chai Jinghua, Holliday Carson, Chan Kara Y, Lujan Hernandez Ana G, Challocombe Zoe, Wang Linya, Han Zhen, Haas Nikhil, Stafford Ryan, Axelrod Fumiko, Yuan Tom Z, De León Diva D, Sato Aaron K
Abstract excerpt
Congenital hyperinsulinism (HI) is a genetic disorder in which pancreatic β-cell insulin secretion is excessive and results in hypoglycemia that, without treatment, can cause brain damage or death. Most patients with loss-of-function mutations in ABCC8 and KCNJ11, the genes encoding the β-cell ATP-sensitive potassium channel (KATP), are unresponsive to diazoxide, the only U.S. Food and Drug...
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