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Article

Functional activation of mutant human insulin receptor by monoclonal antibody.

Lancet (London, England) - 8 Jun 1996

Krook A, Soos M A, Kumar S, Siddle K, O'Rahilly S

Abstract excerpt

BACKGROUND: A mutant insulin receptor, Ser323Leu, has been reported in two severely insulin-resistant patients with Rabson-Mendenhall syndrome. In both cases, extreme hyperglycaemia could not be controlled by conventional antidiabetic therapy. The SER323Leu mutant insulin receptor is inserted normally in the plasma membrane but has very low binding affinity for insulin. A monoclonal antibody directed against the...

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Identifiers

PMID: 8667867
DOI: 10.1016/s0140-6736(96)91076-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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