Functional activation of mutant human insulin receptor by monoclonal antibody.

doi:10.1016/s0140-6736(96)91076-4

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Article

Functional activation of mutant human insulin receptor by monoclonal antibody.

Lancet (London, England) - 8 Jun 1996

Krook A, Soos M A, Kumar S, Siddle K, O'Rahilly S

Abstract excerpt

BACKGROUND: A mutant insulin receptor, Ser323Leu, has been reported in two severely insulin-resistant patients with Rabson-Mendenhall syndrome. In both cases, extreme hyperglycaemia could not be controlled by conventional antidiabetic therapy. The SER323Leu mutant insulin receptor is inserted nor...

Topics

Adult
Animals
Antibodies, Monoclonal
CHO Cells
Cricetinae
Glycogen
Humans
Insulin
Insulin Resistance
Male
Mutation
Phosphorylation
Receptor, Insulin
Syndrome

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