Insulin receptor signaling through non-tyrosine kinase pathways: evidence from anti-receptor antibodies and insulin receptor mutants.

Abstract excerpt

Although there is general agreement that insulin receptor tyrosine kinase activity mediates many of the actions of insulin, two types of studies suggest that non-tyrosine kinase dependent pathways may also exist. First, both monoclonal and polyclonal antibodies to the receptor have been shown to mediate many of insulin's actions with little or no stimulation of receptor kinase. Second, insulin receptor mutants,...

Topics

• Animals
• Antibodies
• Antibodies, Monoclonal
• GTP-Binding Proteins
• Insulin
• Models, Biological
• Mutation
• Protein-Tyrosine Kinases
• Receptor, Insulin
• Signal Transduction
• Type C Phospholipases