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Article

Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer

30 Mar 2011

Abstract excerpt

INTRODUCTION: The IGF-1 receptor (IGF-1R) is a receptor tyrosine kinase and is well established as a key regulator of tumor cell growth and survival. There is also a growing body of data to support a role for the structurally and functionally related insulin receptor (IR) in human cancer. Bidirectional crosstalk between IGF-1R and IR is observed, where specific inhibition of either receptor confers a compensatory...

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PMID: 21446886
DOI: 10.1517/13543784.2011.558501

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