Article

Deep mutational scanning of the human insulin receptor ectodomain to inform precision therapy for insulin resistance

2024-09-08

Abstract excerpt

<h4>Summary</h4> The insulin receptor (INSR) entrains tissue growth and metabolism to nutritional conditions. Complete loss of function in humans leads to extreme insulin resistance and infantile mortality, while loss of 80-90% function permits longevity of decades. Even low-level activation of severely compromised receptors, for example by anti-receptor monoclonal antibodies, thus offers the potential for decisi...

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Literature Corpus work: da44ace5-6630-58f0-9f42-bbf4f0eec48e
DOI: 10.1101/2024.09.07.611782

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