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Dimethyl fumarate modulates the Duchenne muscular dystrophy disease program following short-term treatment in <i>mdx</i> mice

2022-09-17

Abstract excerpt

New medicines are urgently required to treat the fatal neuromuscular disease, Duchenne muscular dystrophy (DMD). DMD involves progressive muscle damage and weakness, which are preceded by oxidative stress, inflammation, and mitochondrial dysfunction. Dimethyl fumarate (DMF) is a potent small molecule nuclear erythroid 2-related factor 2 (Nrf2) activator with current clinical utility in the treatment of multiple sc...

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Literature Corpus work
5e74ec22-02b9-5f81-a4c0-e0a2f4da0151
DOI
10.1101/2022.09.15.508124
Open publication

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Dimethyl fumarate modulates the Duchenne muscular dystrophy disease program following short-term treatment in <i>mdx</i> miceDOI 10.1101/2022.09.15.508124
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