Article

Benfotiamine reduces pathology and improves muscle function in <i>mdx</i> mice

2018-03-25

Abstract excerpt

Duchenne Muscular Dystrophy (DMD) is a progressive and fatal neuromuscular disease which arises from mutations in the dystrophin gene ( DMD ) that result in the absence or severe reduction of the cytoskeletal protein dystrophin. In addition to the primary dystrophin defect, secondary processes such as inflammation, calcium influx, dysregulated autophagy and fibrosis exacerbate dystrophic pathology and thus increa...

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Literature Corpus work: 34fc0d70-4b17-56d8-88b8-2ef2943bed53
DOI: 10.1101/288621

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