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Article

Oxidative stress in Duchenne muscular dystrophy: focus on the NRF2 redox pathway

2 May 2017

Abstract excerpt

Oxidative stress is involved in the pathogenesis of Duchenne muscular dystrophy (DMD), an X-linked genetic disorder caused by mutations in the dystrophin gene and characterized by progressive, lethal muscle degeneration and chronic inflammation. In this study, we explored the expression and signaling pathway of a master player of the anti-oxidant and anti-inflammatory response, namely NF-E2-related Factor 2, in...

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PMID: 28472288
DOI: 10.1093/hmg/ddx173

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