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Article

Targeting Nrf2 for the treatment of Duchenne Muscular Dystrophy

18 Nov 2020

Abstract excerpt

Imbalances in redox homeostasis can result in oxidative stress, which is implicated in various pathological conditions including the fatal neuromuscular disease Duchenne Muscular Dystrophy (DMD). DMD is a complicated disease, with many druggable targets at the cellular and molecular level including calcium-mediated muscle degeneration; mitochondrial dysfunction; oxidative stress; inflammation; insufficient muscle...

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PMID: 33246292
DOI: 10.1016/j.redox.2020.101803

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