Article

Enhancement of Prednisolone efficacy and safety in Duchenne muscular dystrophy via neutrophil elastase inhibition

2025-02-27

Abstract excerpt

<h4>ABSTRACT</h4> Duchenne muscular dystrophy (DMD) is a genetic disorder characterized by muscle wasting, and leading to premature death. The pathogenesis of DMD is complex. It is triggered by loss of the cytoskeletal protein dystrophin, which causes muscle fiber instability and damage, followed by chronic inflammation and fibrotic replacement of damaged muscle tissue. Here we investigated the hypothesis that in...

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Literature Corpus work: ef4e87c3-29a4-5d94-b756-636b95cb06fe
DOI: 10.1101/2025.02.26.640472

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