Article

9p21 Loss Defines the Evolutionary Patterns of Aggressive Renal Cell Carcinomas

2020-11-04

Abstract excerpt

Dedifferentiation and acquisition of chromosomal instability in renal cell carcinoma portends dismal prognosis and aggressive clinical behavior. However, the absence of reliable experimental models dramatically impacts the understanding of mechanisms underlying malignant progression. Here we established an in vivo genetic platform to rapidly generate somatic mosaic genetically engineerd immune-competent mouse mod...

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Literature Corpus work: 5e6302e9-cd75-5d8f-9d79-731b2bfc8c1a
DOI: 10.1101/2020.11.03.367433

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