Article

A single chromosome 3p break initiates clear cell renal cell carcinoma evolution

2026-07-10

Abstract excerpt

<h4>SUMMARY</h4> Clear cell renal cell carcinoma (ccRCC) is initiated by chromosome 3p loss, yet chromosome losses impose a profound fitness burden on normal cells. How renal epithelial cells tolerate this deleterious aneuploidy during early tumorigenesis remains unclear. Analysis of 949 ccRCC genomes reveals two major classes of chromosome 3p alterations: simple deletions and complex rearrangements surrounding a...

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Literature Corpus work: 1d47f61c-6baf-5a06-b470-9612b4f599de
DOI: 10.64898/2026.07.10.737056

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