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Article

Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer

26 Jun 2023

Abstract excerpt

Molecular routes to metastatic dissemination are critical determinants of aggressive cancers. Through in vivo CRISPR-Cas9 genome editing, we generated somatic mosaic genetically engineered models that faithfully recapitulate metastatic renal tumors. Disruption of 9p21 locus is an evolutionary driver to systemic disease through the rapid acquisition of complex karyotypes in cancer cells. Cross-species analysis...

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PMID: 37365326
DOI: 10.1038/s43018-023-00584-1

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