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Article

A mosaic analysis system with Cre or Tomato expression in the mouse.

Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 2020

Wang Qun, Lin Yen-Yu, Zhang Baojun, Wu Jianxuan, Roy Sumedha, Ratiu Jeremy J, Xu Yanping, Dai Meifang, Hale Laura P, Xiong Yue, Li Qi-Jing, Zhuang Yuan

Abstract excerpt

Somatic mutations are major genetic contributors to cancers and many other age-related diseases. Many disease-causing somatic mutations can initiate clonal growth prior to the appearance of any disease symptoms, yet experimental models that can be used to examine clonal abnormalities are limited. We describe a mosaic analysis system with Cre or Tomato (MASCOT) for tracking mutant cells and demonstrate its utility...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33106431
DOI: 10.1073/pnas.2014308117
PMCID: PMC7668046

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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