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Article

The Evolution of Angiogenic and Inflamed Tumors: The Renal Cancer Paradigm.

Cancer cell - 14 Dec 2020

Brugarolas James, Rajaram Satwik, Christie Alana, Kapur Payal

Abstract excerpt

Gene expression analyses have identified subtypes of conventional renal cell carcinoma broadly distributed into angiogenic and proliferative/ immunogenic clades. Integration with genomic and functional experiments in animal models yields an evolutionary model. Evolutionary trajectories illustrate remarkable plasticity, particularly for a tumor that typically begins with inactivation of a single gene.

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Source

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Identifiers

PMID: 33157049
DOI: 10.1016/j.ccell.2020.10.021
PMCID: PMC9807219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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