Evolutionary fingerprints of epithelial-to-mesenchymal transition.

doi:10.1038/s41586-025-08671-2

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Article

Evolutionary fingerprints of epithelial-to-mesenchymal transition.

Nature - 1 Apr 2025

Perelli Luigi, Zhang Li, Mangiameli Sarah, Giannese Francesca, Mahadevan Krishnan K, Peng Fuduan, Citron Francesca, Khan Hania, Le Courtney, Gurreri Enrico, Carbone Federica, Russell Andrew J C, Soeung Melinda, Lam Truong Nguyen Anh, Lundgren Sebastian, Marisetty Sujay, Zhu Cihui, Catania Desiree, Mohamed Alaa M T, Feng Ningping, Augustine Jithesh Jose, Sgambato Alessandro, Tortora Giampaolo, Draetta Giulio F, Tonon Giovanni, Futreal Andrew, Giuliani Virginia, Carugo Alessandro, Viale Andrea, Kim Michael P, Heffernan Timothy P, Wang Linghua, Kalluri Raghu, Cittaro Davide, Chen Fei, Genovese Giannicola

Abstract excerpt

Mesenchymal plasticity has been extensively described in advanced epithelial cancers; however, its functional role in malignant progression is controversial1-5. The function of epithelial-to-mesenchymal transition (EMT) and cell plasticity in tumour heterogeneity and clonal evolution is poorly understood. Here we clarify the contribution of EMT to malignant progression in pancreatic cancer. We used somatic mosaic...

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PMID: 40044861
DOI: 10.1038/s41586-025-08671-2
PMCID: PMC13537484

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