Article

Emergent glutamate & dopamine dysfunction in VPS35(D620N) knock-in mice and rapid reversal by LRRK2 inhibition

2025-03-31

Abstract excerpt

<title>Abstract</title> <p>The D620N variant in Vacuolar Protein Sorting 35 (VPS35) causes autosomal-dominant, late-onset Parkinson’s disease. VPS35 is a core subunit of the retromer complex that canonically recycles transmembrane cargo from sorting endosomes. Although retromer cargoes include many synaptic proteins, VPS35’s neuronal functions are poorly understood. To investigate the consequences of the Parkinso...

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Literature Corpus work: 5e4efb67-aa42-5916-85e9-309f9d6d159f
DOI: 10.21203/rs.3.rs-5167163/v1

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