Article

Endosomal Traffic And Glutamate Synapse Activity Are Increased In VPS35 D620N Mutant Knock-In Mouse Neurons, And Resistant To LRRK2 Kinase Inhibition

2021-07-08

Abstract excerpt

<title>Abstract</title> <p>Vacuolar protein sorting 35 (VPS35) regulates neurotransmitter receptor recycling from endosomes. A missense mutation (D620N) in VPS35 leads to autosomal-dominant, late-onset Parkinson’s disease. Here, we study the basic neurobiology of VPS35 and Parkinson’s disease mutation effects in the D620N knock-in mouse and the effect of leucine-rich repeat kinase 2 (LRRK2) inhibition on synaptic...

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Literature Corpus work: 6da9b213-2d3e-50fc-aa0c-1fa0c17b7626
DOI: 10.21203/rs.3.rs-550445/v2

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