Article

Emergent glutamate & dopamine dysfunction in VPS35 <sub>(D620N)</sub> knock-in mice and rapid reversal by LRRK2 inhibition

2024-10-01

Abstract excerpt

The D620N variant in Vacuolar Protein Sorting 35 (VPS35) causes autosomal-dominant, late- onset Parkinson’s disease. VPS35 is a core subunit of the retromer complex that canonically recycles transmembrane cargo from sorting endosomes. Although retromer cargoes include many synaptic proteins, VPS35’s neuronal functions are poorly understood. To investigate the consequences of the Parkinson’s mutation, striatal neur...

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Literature Corpus work: 2fcb5e16-2b4a-5511-b20e-78c2880eb59c
DOI: 10.1101/2024.09.30.615858

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