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Article

VPS35 D620N knockin mice recapitulate cardinal features of Parkinson’s disease

21 Mar 2021

Abstract excerpt

D620N mutation in the vacuolar protein sorting 35 ortholog (VPS35) gene causes late-onset, autosomal dominant familial Parkinson's disease (PD) and contributes to idiopathic PD. However, how D620N mutation leads to PD-related deficits in vivo remains unclear. In the present study, we thoroughly characterized the biochemical, pathological, and behavioral changes of a VPS35 D620N knockin (KI) mouse model with...

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PMID: 33745227
DOI: 10.1111/acel.13347

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