Article

Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine dynamics in VPS35 p.D620N knock-in mice

2023-05-14

Abstract excerpt

Dysregulation of dopamine neurotransmission profoundly affects motor, motivation and learning behaviors, and is often observed during the prodromal phase of Parkinson’s disease (PD). However, the mechanism underlying these pathophysiological changes remains to be elucidated. Mutations in vacuolar protein sorting 35 ( VPS35 ) and leucine-rich repeat kinase 2 ( LRRK2 ) both lead to autosomal dominant PD, and VPS35...

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Literature Corpus work: 7f9fd91d-f2cf-55c0-9455-cf68e5b4c1d6
DOI: 10.1101/2023.05.14.540654

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