Article

Aneuploidy and deregulated DNA damage response define haploinsufficiency in breast tissues of <i>BRCA2</i> mutation carriers

2019-08-08

Abstract excerpt

Women harboring heterozygous germline mutations of BRCA2 have a 50-80% risk of developing breast cancer, yet the early pathogenesis of these cancers is poorly understood. We sought to reveal early steps in BRCA2 -associated carcinogenesis through analysis of sorted cell populations from freshly-isolated, non-cancerous breast tissues among a cohort of BRCA2 mutation carriers and matched controls. Single-cell who...

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Literature Corpus work: 79f367ba-0926-5d67-a45a-4f662c00395f
DOI: 10.1101/729301

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