Article

Pan cancer patterns of allelic imbalance from chromosomal aberrations in 33 tumor types

2019-05-10

Abstract excerpt

<h4>ABSTRACT</h4> Somatic copy number alterations (SCNAs), including deletions and duplications, serve as hallmarks of tumorigenesis. SCNAs may span entire chromosomes and typically result in deviations from an expected one-to-one ratio of alleles at heterozygous loci, leading to allelic imbalance (AI). The Cancer Genome Atlas (TCGA) reports SCNAs identified using a circular binary segmentation (CBS) algorithm, p...

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Literature Corpus work: 4e3f98df-7129-59c7-9a82-3746a63e95f1
DOI: 10.1101/635193

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