Article

High Impact Mutation Burden and Integrated Genomic Instability Reveal Subtype-Specific Divergence in Breast Cancer

2025-11-05

Abstract excerpt

<title>Abstract</title> <p>Genomic instability (GI) is a defining feature of cancer, yet its clinical role in breast cancer remains uncertain. Tumor mutational burden (TMB), high-impact mutation burden (HIMB), and aneuploidy are widely studied, but their relative contributions to prognosis versus therapy prediction have not been systematically compared. We analyzed 1,084 breast cancers from The Cancer Genome Atla...

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Literature Corpus work: bc6b79c1-7a3f-599c-a965-91ee9e2fc06a
DOI: 10.21203/rs.3.rs-7675619/v1

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