Article

Single-Cell full-length Isoform Sequencing Unveils Transcriptional Dysregulation in Autism Spectrum Disorder During Cerebral Cortex Development

2024-12-04

Abstract excerpt

<h4>ABSTRACT</h4> Regulation of RNA splicing is pivotal in neural development, with established gene isoform expression patterns ( 1, 2 ). However, the specific roles of isoform diversity across cell types in both healthy and diseased brains warrant further investigation. Here, we employed a combination of metabolic RNA labeling using 4-thiouridine (4sU) and long-read sequencing based single-cell full-length tra...

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Literature Corpus work: 7ee96848-64fd-5cb2-bf28-a6f850c1090f
DOI: 10.1101/2024.12.04.626807

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