Article

Uncovering the dark transcriptome in polarized neuronal compartments with mcDETECT

2025-04-01

Abstract excerpt

Spatial transcriptomics (ST) is a powerful tool for studying the molecular basis of brain diseases. However, most current analyses focus only on nuclear or somatic expression, overlooking distally localized mRNAs, known as the “dark transcriptome.” These transcripts, which make up nearly 40% of the brain transcriptome, are packaged into RNA granules and transported to polarized neuronal structures critical for neu...

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Literature Corpus work: 0820ec99-8801-54d5-9a17-504996597d65
DOI: 10.1101/2025.03.27.645744

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