Article

Deep learning and direct sequencing of labeled RNA captures transcriptome dynamics

2023-11-17

Abstract excerpt

Quantification of the dynamics of RNA metabolism is essential for understanding gene regulation in health and disease. Existing methods rely on metabolic labeling of nascent RNAs and physical separation or inference of labeling through PCR-generated mutations, followed by short-read sequencing. However, these methods are limited in their ability to identify transient decay intermediates or co-analyze RNA decay wit...

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Literature Corpus work: d7da443c-132c-5884-8a74-e2f9a5f785ef
DOI: 10.1101/2023.11.17.567581

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