Article

Nicotinamide N-Methyltransferase drives fibroblast activation and skin fibrosis in systemic sclerosis

2025-10-27

Abstract excerpt

<h4>Background</h4> In systemic sclerosis (SSc), an autoimmune response leads to progressive fibrosis of the skin and internal organs, driven by aberrant activation of fibroblasts. The mechanisms dictating persistent dermal fibroblast (DF) activation and production of extracellular matrix (ECM) remain poorly understood. Nicotinamide N-methyltransferase (NNMT), a SAM-consuming enzyme that modulates cellular methyl...

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Literature Corpus work: 5e07ce61-ea0c-5e5a-8a41-8bc295ff6151
DOI: 10.1101/2025.10.27.684733

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