Article

Altered AP-1, RUNX and EGR chromatin dynamics drive fibrotic lung disease

2024-10-28

Abstract excerpt

Pulmonary fibrosis, including systemic sclerosis-associated interstitial lung disease (SSc-ILD), involves myofibroblasts and SPP1 hi macrophages as drivers of fibrosis. Single-cell RNA sequencing has delineated fibroblast and macrophages transcriptomes, but limited insight into transcriptional control of profibrotic gene programs. To address this challenge, we analyzed multiomic snATAC/snRNA-seq on explanted SSc-...

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Identifiers and source

Literature Corpus work: 194ba94c-3446-5738-b99a-f5da9afe5ed5
DOI: 10.1101/2024.10.23.619858

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