Back to search

Article

Spatial Orchestration of Skin Fibrosis by a CD8+ T cell-Myofibroblast Axis

2026-06-22

Abstract excerpt

<h4>ABSTRACT</h4> Fibrosing skin diseases are highly morbid conditions with diverse clinical and histopathologic features. Prior work, primarily in systemic sclerosis (SSc), has yielded mixed data regarding the immune drivers of fibrosis, as well as the identity and spatial localization of pro-fibrotic fibroblast cell subsets. Here, we focus on morphea and eosinophilic fasciitis (EF), which cause more acutely inf...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
88c19501-ec67-57af-856e-cec35f84fa2d
DOI
10.64898/2026.06.17.732787
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Spatial Orchestration of Skin Fibrosis by a CD8+ T cell-Myofibroblast AxisDOI 10.64898/2026.06.17.732787
Mapping spatially-resolved transcriptomes in systemic sclerosisSemantic proximity
A single cell and spatial genomics atlas of human skin fibroblasts in health and diseaseSemantic proximity
Sex-biased Fibroblast Subpopulations and Transcriptional Programs Reveal Mechanisms of Skin Lesion Development in Systemic SclerosisSemantic proximity
Single-Cell Transcriptome Analysis Identifies Subclusters with Inflammatory Fibroblast Responses in Localized SclerodermaSemantic proximity
Cellular census of human fibrosis defines functionally distinct stromal cell types and statesSemantic proximity
New insight into the role of fibroblasts in the epithelial immune microenvironment in the single-cell eraSemantic proximity
Profiling Fibrosis through Single-Cell and Spatial Transcriptomics Analysis: cell identity and tissue architectureSemantic proximity
Deconstruction of immune-mediated skin diseases defines six inflammatory subtypes.Semantic proximity
A Transcriptomic Atlas of Healthy Human Skin Links Regional Identity to Inflammatory DiseaseSemantic proximity
Imaging mass cytometry-based characterisation of fibroblast subsets and their cellular niches in systemic sclerosisSemantic proximity
Lupus dermal fibroblasts are proinflammatory and exhibit a profibrotic phenotype in scarring skin disease.Semantic proximity
Dynamic pathological analysis reveals a protective role against skin fibrosis for TREM2-dependent macrophagesSemantic proximity
Select a neighboring publication to make it the new centre.